Products & Services

Colorectal cancer organoids

Cellesce has initially focused on a range of ten colorectal cancer organoids. These reflect the genetic diversity found in the major colorectal cancer sub-types. Full gene sequencing, RNA expression and drug response data are provided for each organoid. These are now available in commercial quantities at drug profiling scale.

Colorectal organoids

Example images of five of our ten colorectal organoid lines. Confocal images using 20X objective of Cell Insight Cx7. Organoids stained for nuclear (blue) and cytoskeletal (red) markers for imaging. Scale 50μm

  • Organoids provided in frozen cryovials, ready for seeding into assay format. Each vial contains c.500 data points*
  • Derived from patient tissue from a range of colorectal sites and TNM stages
  • Analysed for key driver mutations,using the SureSeq™ Solid Tumour Panel from OGT (including but not limited to: APC, BRAF, EGFR, HRAS, KRAS, PDGFR, PIK3CA, PTEN, TP53, VHL)
  • In-house validated against a number of known CRC targeting agents
  • Varied morphologies and growth profiles

*Based on assays performed in 384 well format

Custom organoid expansion services

  • Expansion of your own organoid lines or line derivation from PDX tissue
  • Using your current protocols, Cellesce will work to determine optimum condiditons for expansion in our systems, before expanding and supplying back to you in your desired quantities

Coming soon

  • Wild type ‘normal’ colorectal lines, prostate, breast and organoids of other tissue types
  • We are also developing larger scale systems to allow provision of vials at a high-throughput drug screening level.
© Cellesce Ltd 2018