Organoids – Method of the Year

In the last few years fundamental cell biology research has moved from studies in two dimensions (2D) looking at cells on flat plastic plates to more comprehensive tools and understanding of how cells work in three dimensions (3D) both singly and in connection to other cells. 3D cell aggregates can be random constructs, or as in the case of organoid culture,  organised multicellular-matrix structures that recapitulate human tissue and organs.
organoids - method of the year

The Nature Methods journal has awarded ‘organoids’ the method of the year

Organoids represent such exciting tools, models and potential for fundamental human biology that the journal Nature Methods has hailed them as their Method of the Year for 2017. In the January 2018 issue (Volume 15, No 1) Nature Methods has focused on the fundamentals and the potential of organoids to be used: as models in mammalian development, as tools to study biological processes; and as models for disease. In addition to research uses, Cellesce is commercially developing organoids as models for drug discovery, further exploiting their recapitulation of human organ characteristics to give in vivo-like drug responses. For readers who are new to the organoid field, the commentary and papers in this special issue of Nature Methods provide a good starting point to understand their basics and their exciting potential for the future.